Rio Ferdinand may feature for Manchester United after initial examinations showed his groin injury is not a long-term problem.
But a Saturday return for him and John O'Shea (calf) are more likely, so Darren Fletcher may be at right-back, while Craig Cathcart, 18, eyes a debut.
Sheffield United centre-back Claude Davis is almost certainly out with an ankle injury sustained at the weekend.
Striker Jon Stead also has a knock and may not figure.
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Man Utd (from): Van der Sar, Kuszczak, O'Shea, Fletcher, Cathcart, Ferdinand, Brown, Heinze, Evra, Ronaldo, Carrick, Scholes, Giggs, Richardson, Rooney, Smith, Solskjaer, Dong.
Sheffield United (from): Kenny, Bromby, Davis, Morgan, Jagielka, Shelton, Stead, Hulse, Webber, A Quinn, Kozluk, Kilgallon, Montgomery, Tonge, Gillespie, Armstrong, Leigertwood, Lucketti, Fathi, Geary, Nade, S Quinn, Kazim-Richards, Bennett.
Arsenal vs. Man City
Arsenal's Abou Diaby and Julio Baptista are both pressing for a recall.
But Thierry Henry (groin and stomach), Freddie Ljungberg (hamstring), Theo Walcott (shoulder) and Robin van Persie (broken foot) are all sidelined.
Manchester City striker Emile Mpenza is a doubt with the hip injury which forced him to be substituted in the 0-0 draw with Liverpool.
Belgian Mpenza has given City a lift since his arrival and will be given as much time as possible to recover.
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Arsenal (from): Lehmann, Eboue, Toure, Gallas, Clichy, Hleb, Fabregas, Gilberto, Rosicky, Ljungberg, Adebayor, Almunia, Diaby, Baptista, Senderos, Aliadiere, Denilson, Djourou.
Man City (from): Isaksson, Weaver, Onuoha, Trabelsi, Sun, Dunne, Distin, Ball, Jordan, Sinclair, Ireland, Barton, Hamann, Johnson, Dabo, Beasley, Vassell, Mpenza, Corradi, Samaras.