John Toshack's side have lost two of their first three Euro 2008 qualifiers but have four more months to prepare for their next competitive game, against Republic of Ireland, and will view this friendly as the perfect opportunity to find some form.
However, injuries to key defenders James Collins, Gareth Bale and Danny Gabbidon have hit Toshack's plans.
Collins (groin) and Bale (back) have had to pull out of the game after picking up injuries at the weekend, while Gabbidon remains a serious doubt with a back problem.
With Mark Delaney also missing due to knee trouble, Craig Morgan, Lewin Nyatanga, Richard Duffy and Sam Ricketts are set to line up in defence.
Steve Evans of Wrexham is expected to start on the bench but could come on to make his debut on his home ground.
Blackburn's Jason Brown looks set to replace the absent Paul Jones in goal, with Simon Davies, Ryan Giggs, Jason Koumas and Carl Robinson the likely midfield quartet and Craig Bellamy and Robert Earnshaw up front.
Giggs will make his 60th appearance for Wales, but the 32-year-old has played down suggestions he could be a long-term successor to Toshack.
"I still have not thought about what I will do after football, coaching or management hasn't really been considered yet," he insisted.
"I am so concentrated on football and being a good player, I don't think about what will happen.
"You see some players you think are nailed on to be managers, and they don't make it. But then you look at Mark Hughes, outside the game people would not seehim as a manager.
"But he fell into the job as Wales manager and then has gone on to do so well with Blackburn. A lot of it is fate, a lot of players are focused on it and know they will be managers.
"At the moment I am just focused on being a player, nothing else just yet."
Liechtenstein will be playing their first match under new coach Urs Meier, who has been put in temporary charge following Martin Andermatt's defection to Swiss club Young Boys.
Liechtenstein, who have lost their last nine games, have brought an 18-man squad to Wales.